Transplanted Kidneys May Soon Overcome Rejection

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In efforts to put a stop to the age-old dilemma of organ rejection among kidney transplant patients, science is almost on the verge of new breakthroughs to ensure making it last a lifetime for the host.

This after medical researchers have already gone through leaps and bounds in diagnosing potential organ rejection scenarios and predicting possible failure situations by going deeper into molecular profiling that would determine the perfect match of the organ with the host.

Statistics show that recent technologies and methods of kidney transplants have shown significant results with 97% of new kidneys are fully-functional at the end of the first month, subsequently followed by a 93% success rate at the end of 1 year and 83% by the end of 3 years.

Compared to 10-15 years ago when more than 70 percent of kidney transplants often lasts for one year at most and the host starts to reject the transplanted organ.

This is primarily due to rejection where the immune system responds to the ‘new’ organ and starts attacking it slowly until it gets destroyed or expires.

There are basically two types of rejection that takes place, acute and chronic, where the former happens rapidly the process takes up one year at most, while chronic rejection develops slowly and may last for several years until the organ ends up in complete failure.

Latest research findings published by the American Journal of Transplantation indicated that out of 234 kidney biopsies conducted for possible transplant to new hosts, it was found out that 80% of the genes that promote acute rejection have the same tissues among chronic rejection kidneys.

The Scripps Research Institute (TSRI) that spearheaded the study discovered that both rejection types are not separate conditions, but belong to the same gene pool.

Prof. Daniel Salomon, TSRI director for Laboratory for Functional Genomics, confirmed these findings and would now help researcher develop more methods to help prolong kidney longevity among its hosts.

Molecular profiling through better technologies would now be able to find perfect matches with hosts and may someday even take a step further by making the most out of effective treatments to  allow the kidneys to be adapted by the host throughout its lifetime.

In the United States, 26 million Americans have kidney disease and most of them are not aware that they have it, especially for those with suffering from high blood pressure and diabetes.

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